1. Irritate the entire digestive tract.

2. Upset the ph of the stomach and digestive process.

3. Artificially stimulate peristalsis.

4. Aggravate the nervous systems.

5. Cause cramping and discomfort.

6. Are unpredictable.

7. May give instant relief, but potential long term damage to the lining of the digestive system.

8. Cause dehydration since they move the chyme through too quickly interrupt water absorption to cells.

9. Create a vicious cycle of diarrhea / constipation / diarrhea / constipation / diarrhea / constipation.

10. Cause weakness in the colon muscles and potential ballooning and strictures.

11. Long term use can reduce muscle tone and the colon become distorted.

12. Cause excess mucous build up to protect and shield the colon from the irritation.

13. Ultimately, they cause a worse constipation problem.

14. Finally, they no longer work.